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Postulated Gastric Factor Enhancing Iron Absorption in Haemochromatosis
Author(s) -
Smith Paul M.,
Studley Frances,
Williams Roger
Publication year - 1969
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1969.tb00422.x
Subject(s) - hemochromatosis , ascorbic acid , pylorus , iron deficiency , medicine , absorption (acoustics) , jejunum , intrinsic factor , gastroenterology , chemistry , endocrinology , stomach , biochemistry , food science , materials science , anemia , composite material
Summary: A variety of everted gut sac techniques have been used to determine if there is a factor in neutralized gastric juice from patients with haemochromatosis and iron deficiency which will potentiate iron absorption, as suggested by Murray (1968). No such effect was found and iron uptake by the sacs did not correlate with measurements of iron absorption in the patients with haemochromatosis using a whole body counter. Peak iron uptake was found to occur from between 12 to 24 cm. from the rat pylorus, in the jejunum. Ascorbic acid enhanced iron transfer from the mucosal to the serosal surface but no evidence for an active transport system was found.