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Changes in Factors V and VIII after Administration of Adrenaline to Normal and Splenectomized Rats
Author(s) -
Pudlaak P.,
Farská I.,
Deimlová E.
Publication year - 1969
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1969.tb00414.x
Subject(s) - medicine , endocrinology , nephrectomy , body weight , kidney
Summary: Changes in Factors V and VIII were studied in normal, unilaterally nephrectomized, and splenectomized rats. Adrenaline in a dose of 3 or 6 μg. per 200 g. body weight subcutaneously induced a significant but not very large increase in the activity of Factors V and VIII. A similar increase occurred in splenectomized and unilaterally nephrectomized rats. However, after unilateral nephrectomy an injection of adrenaline did not further raise the concentration of Factor VIII; and in Splenectomized rats a decrease in Factor VIII was found after adrenaline. The level of Factor V was not further significantly altered in either operated group after giving adrenaline. The mechanism of these changes is discussed but remains to be elucidated.