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Anomalies of Blood Group Antigens and Erythrocyte Enzymes in Two Types of Chronic Refractory Anaemia
Author(s) -
Dreyfus B.,
Sultan C.,
Rochant H.,
Salmon Ch.,
Mani P.,
Cartron J. P.,
Boivin P.,
Galand C.
Publication year - 1969
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1969.tb00404.x
Subject(s) - enzyme , antigen , pyruvate kinase , red cell , abo blood group system , refractory (planetary science) , bone marrow , medicine , immunology , biology , mutase , glycolysis , biochemistry , astrobiology
Summary: Blood‐group antigens and erythrocyte glycolytic enzyme activities were studied in II cases of refractory anaemia consisting of seven cases of refractory anaemia with excess of myeloblasts in bone marrow and four cases of acquired sideroblastic anaemia. Some significant modifications of the amounts of A, A 1 , B, H, I and i antigens were found in 10 cases. Some enzyme deficiencies involving pyruvate kinase, 2–3‐diphosphoglycerate mutase and phosphofructokinase were observed. In addition, several populations of pathological red cells showing distinct antigenic abnormalities were demonstrated in one patient. A new type of anaemia with acquired multiple and varied enzyme anomalies of the red‐cell series has therefore been defined. Its links with acute leukaemia are discussed.