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Congenital Thrombocytopenia with Giant Platelets: a Defect in the Platelet Membrane
Author(s) -
Gröttum Kjell A.,
Solum Nils Olav
Publication year - 1969
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1969.tb00402.x
Subject(s) - platelet , sialic acid , membrane , chemistry , medicine , biophysics , immunology , biochemistry , biology
Summary: Three patients with congenital macrothrombocytic thrombocytopenia are described. The platelets had a reduced electrophoretic mobility, and the content of sialic acid was also abnormally low, suggesting a defect in the platelet membrane. Platelets were rapidly removed from the circulation, possibly because the platelet membrane defect was associated with reduced electrostatic repulsive forces.

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