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The Absorption of Pteroylglutamic (Folic) Acid in Rats
Author(s) -
Hefner G. W.
Publication year - 1969
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1969.tb00399.x
Subject(s) - jejunum , ileum , absorption (acoustics) , methotrexate , chemistry , in vivo , folic acid , medicine , endocrinology , pharmacology , biochemistry , biology , materials science , microbiology and biotechnology , composite material
Summary: Absorption of crystalline folic acid (pteroylglutamic acid—PGA) was studied in rats, using tritiated PGA and an in vivo absorption technique. Increasing doses of PGA were introduced into the jejunum and ileum: the percentage absorption fell with increasing doses in the jejunum, suggesting the presence of an active transport mechanism, whereas percentage absorption in the ileum remained constant for all doses, suggesting that absorption occurred by passive diffusion. Phenytoin and methotrexate put into the jejunum immediately before PGA partly inhibited its absorption, as did subcutaneous methotrexate given 3 hours before the PGA was administered. Methotrexate had no effect on the ileal absorption of PGA, nor on the absorption of D‐xylose in the jejunum.