Premium
Cell Population Kinetics of the Erythroid System in the Rat. The Response to Protracted Anaemia and to Continuous γ‐Irradiation
Author(s) -
Tarbutt R. G.
Publication year - 1969
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1969.tb00374.x
Subject(s) - outflow , inflow , population , irradiation , kinetics , andrology , compartment (ship) , biology , chemistry , erythropoiesis , endocrinology , medicine , immunology , anemia , oceanography , physics , environmental health , quantum mechanics , meteorology , mechanics , nuclear physics , geology
Summary: Estimates have been obtained of the parameters defining the cell population kinetics of the erythroid system in rats subjected to protracted anaemia and to continuous γ‐irradiation at 43 rad/day. The inflow of cells to the proerythroblast compartment and the outflow of erythrocytes to the circulation have been measured by 55 Fe autoradiography. In the anaemic rats, the ratio of the outflow to the inflow is normal, indicating that the precursors undergo the normal number of divisions during maturation from proerythroblast to erythrocyte. In the continuously irradiated rats, the outflow is normal but the inflow is decreased by a factor in the range 2–4, so that the ratio of the outflow to the inflow is increased by this factor, and the cells undergo more divisions than normal during maturation. The cell proliferation parameters of the various maturation stages of the erythroid system have been determined in anaemic rats, using 3 H‐TdR autoradiography. The number of divisions undergone during maturation through each stage is normal, but the maturation times and cycle times are considerably reduced. Less information is available on the proliferation parameters in the continuously irradiated rats, but the 55 Fe experiments indicate that the transit times of the proerythroblasts and of the non‐dividing stages of the system are increased in response to this stress.