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Quantitative Histology of Spleen Colonies in Irradiated Mice
Author(s) -
Silini G.,
Pons S.,
Pozzi L. V.
Publication year - 1968
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1968.tb07000.x
Subject(s) - spleen , bone marrow , biology , histology , pathology , microbiology and biotechnology , myeloid , immunology , medicine , genetics
S ummary . Quantitative histological examinations were carried out on large numbers of spleen nodules obtained in heavily irradiated mice by injection of bone‐marrow and foetal liver cell suspensions. Endogenous colonies and clones arising from irradiated bone‐marrow cells have also been analysed. It was found that the large majority of clones consisted of cells of either erythroid or myeloid or mega‐karyocytic type. A smaller percentage of clones were mixed with association of the various cell types in all possible combinations. Statistical analysis of the data revealed consistent differences in the distribution of clones derived from various sources. Attention is particularly focused on the mixed clones with a discussion of their significance in the light of the mono‐ or poly‐phyletic origin of blood cells.