Premium
The Ultrastructure of Bone Marrow Histiocytes in Megaloblastic Anaemia and the Anaemia of Infection
Author(s) -
Goodman J. R.,
Wallerstein R. O.,
Hall S. G.
Publication year - 1968
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1968.tb06998.x
Subject(s) - histiocyte , pathology , staining , phagocytosis , bone marrow , ultrastructure , hemosiderin , medicine , biology , immunology
S ummary . An electron‐microscopic study was made of the iron in the histiocytes in niegaloblastic anaemia and in the anaemia of infection. The particulate iron seen by Prussian Blue staining in the histiocytes in megaloblastic anaemia was demonstrated by electron microscopy to be bound in the vesicles, while the diffuse iron staining in the anaemia of infection was related to the free dispersion of iron‐containing particles in the cytoplasm of the histiocytes. The phagocytosis of erythroblasts at various stages of maturity occurred in cases of niegaloblastic anaemia and resulted in a picture showing every stage of degradation. Phagocytosis of erythroblasts by histiocytes was not seen in the marrows of patients with the anaemia of infection nor did it occur in niegaloblastic anaemia in remission.