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Further Observations on Patients with a Chromosomal Abnormality Associated with Polycythaemia Vera
Author(s) -
Millard Rosemary E.,
Lawler Ylvia D.,
Kay H. E. M.,
Cameron C. B.
Publication year - 1968
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1968.tb06988.x
Subject(s) - bone marrow , polycythaemia , pancytopenia , abnormality , pyridoxine , chromosome abnormality , pathology , medicine , karyotype , population , chromosome , biology , gastroenterology , genetics , environmental health , psychiatry , gene
S ummary . An abnormality resembling a deletion of a chromosome of the F(19–20) group was observed in the bone‐marrow cells in seven patients with polycythaemia Vera. Five of the patients had a history of 9 years or more; six had received 32 P (24.5 mCi or more) and one busulphan only. Cells with the abnormality constituted 22–100 per cent of the bone‐marrow population, but were very seldom observed in blood cultures. In one bone‐marrow aspirate which was examined there was no special pattern of DNA synthesis of the abnormal chromosome. One case was examined before and after the onset of bone‐marrow failure; coinciding with the appearance of blast cells in the bone marrow, cells with an additional C‐group chromosome were found. The excretion of tryptophane metabolites was studied in five of the cases; it was abnormally high in four and was reduced following pyridoxine. This suggests a relative deficiency of pyridoxine; possibly cells with the deleted F chromosome have a proliferative advantage in this environment.