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Concentrative Uptake of Glycine‐1‐ 14 C by Erythrocytes in Iron‐Deficiency Anaemia
Author(s) -
Iyer G. Y. N.
Publication year - 1968
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1968.tb01578.x
Subject(s) - sarcosine , glycine , iron deficiency , chemistry , potassium , sodium , extracellular , metabolism , biochemistry , medicine , amino acid , anemia , organic chemistry
In iron‐deficiency anaemia erythrocytes concentrate added glycine‐1‐ 14 C establishing cellular: extracellular distribution ratios distinctly higher than normal. This uphill transport is abolished at low temperature and by substitution of a potassium rich, sodium poor medium. lodoacetamide is inhibitory. Added glycine and sarcosine also reduce the distribution ratio. The uptake of glycine is considered in the light of known changes in erythrocyte metabolism and age in iron‐deficiency anaemia.