Premium
Effects of Three Mamba Venoms on the Haemostatic Mechanism
Author(s) -
MacKay N.,
Ferguson J. C.,
McNicol G. P.
Publication year - 1968
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1968.tb01577.x
Subject(s) - thromboplastin , plasmin , partial thromboplastin time , pharmacology , chemistry , platelet , venom , biochemistry , medicine , immunology , coagulation , enzyme
The venoms of three mambas ( Dendroaspis angusticeps, Dendroaspis polylepis and Dendroaspis jamesoni ) were shown to be anticoagulant, an effect due largely to interference with the blood thromboplastin mechanism. The venoms were also capable of inhibiting platelet aggregation and reactivity to ADP. All three venoms possessed proteolytic properties but paradoxically reduced euglobulin clot lysis activity. When studied in purified systems this effect was shown to be due to uncompetitive inhibition of plasmin.