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A Study of ‘Haemosiderin’in the Marrow of the Femur of Normal Young Adult Rabbits Compared with that in Rabbits 4 Months after an Intravenous Injection of 239 Pu(NO 3 ) 4
Author(s) -
Beno Milan
Publication year - 1968
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1968.tb01569.x
Subject(s) - femur , bone marrow , medicine , pathology , nuclear medicine , surgery
A study of the distribution of cells containing iron, as demonstrated by Perls’reagent, in the marrow of the femur of normal young adult rabbits in comparison with that in rabbits of the same age group 4 months after an intravenous injection of 239 Pu(NO 3 ) 4 is described. The number of iron containing cells, which are probably macrophages, was found to be variable in the length of the bone and also from one normal rabbit to another. The amount of pigment in any one cell was also variable. A significant increase in the number of iron containing cells and in the amount of pigment the cells contained was noted in the marrow of the femur of rabbits 4 months after a single intravenous injection of 239 Pu(NO 3 ) 4 , compared with the normal controls. 239 Pu aggregates close to the mineralized surface were not characteristically associated with haemosiderin. This work was carried out at the Medical Research Council Unit for Research on Bone‐Seeking Isotopes, Oxford, while the author was holding a World Health Organization Fellowship. I am indebted to Dr. Janet Vaughan and Mrs. Betty Bleaney for much helpful advice and discussion. I also wish to thank Dr. David Taylor, Department of Biophysics, The Royal Cancer Hospital, for injecting the rabbits with 239 Pu(NO 3 ) 4 . I appreciate the technical help of Mr. John Halfacre.