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The Mechanism of Action of Human Placental Lactogen on Erythropoiesis
Author(s) -
Jepson J. H.,
Friesen H. G.
Publication year - 1968
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1968.tb01566.x
Subject(s) - endocrinology , erythropoiesis , medicine , human placental lactogen , erythropoietin , mechanism of action , anabolism , placental lactogen , biology , fetus , pregnancy , placenta , anemia , in vitro , biochemistry , genetics
A purified preparation of human placental lactogen (HPL) increased the incorporation of 59 Fe into erythrocytes of polycythaemic mice, an effect which was abolished by its incubation with anti‐HPL but not with anti‐sheep erythropoietin (anti‐ESF). The erythropoietic‐stimulating capacity of HPL was abolished by increasing the endogenous concentration of anti‐ESF prior to injection of HPL into plethoric mice, indicating that some ESF was required for the effect of HPL to become apparent. The main action of HPL appeared to be through an augmentation of the erythropoietic effect of ESF in intact and hypophysectomized plethoric and nonplethoric mice through its specific and general anabolic action on erythropoiesis. A similar effect may occur during human pregnancy.