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Thrombopoietin Activity in Idiopathic Thrombocytopenic Purpura
Author(s) -
Choi Sun I.,
McClure P. D.,
Vranic Magda
Publication year - 1968
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1968.tb01548.x
Subject(s) - thrombopoietin , medicine , platelet , thrombocytopenic purpura , immunology , biology , stem cell , genetics , haematopoiesis
In this study we have attempted to measure thrombopoietic activity in patients with idiopathic thrombocytopenic purpura. The activity was more readily detectable in serum than in urine. When a high level of thrombopoietic activity was found, it was often followed within a few days by a rise in platelet count. Activity was significantly elevated only in acute and recurrent ITP, although a suggestive increase was found in chronic ITP. Patients with iron deficiency had no thrombopoietic activity in this assay, even though many of them had elevated platelet counts.