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Relationship between Membrane Function and Permeability II. THE INTERRELATIONSHIP OF COPPER ATTACHMENT, GLYCEROL TRANSPORT AND THROMBOPLASTIN AVAILABILITY IN THE INTACT HUMAN ERYTHROCYTE
Author(s) -
Cohen Phin
Publication year - 1968
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1968.tb01536.x
Subject(s) - glycerol , copper , chemistry , permeability (electromagnetism) , facilitated diffusion , membrane , penetration (warfare) , biochemistry , biophysics , biology , organic chemistry , operations research , engineering
Glycerol in trace amounts appears to enhance exponentially the attachment of trace amounts of copper to human erythrocytes, while its own penetration of the erythrocytes is unaffected. At higher concentrations of glycerol its effect in enhancing copper attachment is abolished. At higher concentrations of copper, glycerol transport is delayed as shown by the PF‐3 availability test in which glycerol is used as the probing agent and the erythrocytes as the source of PF‐3 activity. The copper effect on the glycerol‐induced PF‐3 availability may be surmounted by a surfeit of glycerol. Using these findings, along with some assumptions based upon other data in the literature, a new theory interrelating glycerol and copper transport and thromboplastin availability in the intact erythrocyte has been presented.