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Electron‐Microscopical Study of Bone Marrow Cells in a Case of Chediak‐Higashi‐Steinbrinck Syndrome
Author(s) -
Efrati Pinhas,
Da David
Publication year - 1968
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1968.tb01526.x
Subject(s) - chédiak–higashi syndrome , electron microscope , cytoplasm , phase contrast microscopy , bone marrow , pathology , biology , chemistry , microbiology and biotechnology , medicine , physics , optics
Phase‐contrast and electron‐microscope studies of bone marrow cells in a case of Chediak‐Higashi‐Steinbrinck syndrome are presented. Phase‐contrast microscopy shows giant granules in young granulocytes and in dividing cells. The electron‐microscopical findings are generally in agreement with similar studies by other authors. In addition, structures similar to leucocyte giant granules were observed in erythrocytes. The syndrome seems to be associated with a defective membrane stability of cytoplasmic granules and membrane‐bound lysosomes.