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Alkaline Phosphatase Activity in Immature Granulocytes
Author(s) -
Malasková Věra,
Fuksová Jiřina
Publication year - 1968
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1968.tb01520.x
Subject(s) - promyelocyte , blast crisis , alkaline phosphatase , granulocyte , chronic myeloid leukaemia , precursor cell , myeloid , immunology , phosphatase , myeloid cells , myeloid leukaemia , chemistry , biology , pathology , medicine , biochemistry , enzyme , cell
A positive reaction for alkaline phosphatase activity in granulocyte precursors (myelocytes, promyelocytes and even some blast cells) has been observed in three patients. Two of them had a blastic crisis of subacute or chronic myeloid leukaemia. In the third patient with a blastic crisis of a myeloproliferative syndrome, AP activity was unusually high in pseudo‐Pelger forms of neutrophils from the myelocyte stage onwards. All other cytochemical reactions were normal and in accordance with the myeloid character of the blast cells. The nature of the cells involved and possible explanations of this unusual finding are discussed.