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The Effects on Iron Absorption of Gastro‐intestinal Secretions from Patients with Iron‐Deficiency Anaemia and Haemochromatosis
Author(s) -
Murray M. J.,
Stein Nell
Publication year - 1968
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1968.tb01514.x
Subject(s) - iron deficiency , medicine , hemochromatosis , gastroenterology , stomach , dietary iron , endocrinology , anemia
We have investigated the effects of gastric and intestinal secretions from normal human subjects and those with iron‐deficiency anaemia and haemochromatosis on the in vitro uptake of 59 Fe by everted rat gut segments. Whereas gastric secretions from normal subjects did not potentiate the uptake, intestinal secretions did. This effect was more marked with gastric and intestinal secretions obtained from patients with iron‐deficiency anaemia and haemochromatosis, but it disappeared with prior heating. These findings suggest that gastric and intestinal secretions play a role in the regulation of iron absorption.