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Metabolism of 5‐MethyItetrahydrofolate in Pernicious Anaemia
Author(s) -
Chanarin I.,
Perry Janet
Publication year - 1968
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1968.tb01500.x
Subject(s) - pernicious anaemia , urine , folic acid , megaloblastic anaemia , medicine , excretion , endocrinology , metabolic clearance rate , metabolism , pharmacokinetics
S ummary 5‐Methyltetrahydropteroylglutamic acid was given intravenously to control subjects and to patients with untreated megaloblastic anaemia. The rate of clearance of this substance from the plasma and excretion into the urine after an intravenous dose of 5 μg./kg. of body weight was followed. The rate of clearance was faster in patients with folate deficiency as compared to control subjects. In pernicious anaemia the clearance was either within the normal range or more rapid than normal if there was associated folate deficiency. No support was obtained for the hypothesis that in pernicious anaemia there is a failure to utilize 5‐methylfolate.