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Pyridoxine and Riboflavin Status in the Paterson — Kelly Syndrome
Author(s) -
Jacobs A.,
Cavill I. A. J.
Publication year - 1968
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1968.tb01484.x
Subject(s) - pyridoxine , riboflavin , pyridoxal phosphate , transaminase , red cell , pyridoxal , pyridoxine deficiency , medicine , endocrinology , chemistry , biochemistry , enzyme , cofactor
S ummary A study of 25 patients with the Paterson‐Kelly syndrome shows them to have a normal red cell total riboflavin content. This suggests that riboflavin deficiency is not an important factor in this condition. There is a reduction of red cell transaminase activity which can be stimulated in vitro by pyridoxal phosphate. In three cases the administration of pyridoxine resulted in an in viva rise in red cell transaminase activity. Some degree of pyridoxine deficiency appears to be common in the Paterson‐Kelly syndrome.