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The Metabolism of Iron‐Dextran Given as a Total‐Dose Infusion to Iron Deficient Jamaican Subjects *
Author(s) -
Wood J. K.,
Milner P. F. A.,
Pathak U. N.
Publication year - 1968
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1968.tb01481.x
Subject(s) - spleen , urine , metabolism , bone marrow , chemistry , medicine , endocrinology
S ummary The movements of iron‐dextran, following a total dose infusion of up to 2550 mg. iron in six severely iron deficient patients, have been studied using a 59 Fe tagged complex. The preparation is removed from the plasma in 8–10 days. Fifty per cent of the iron was incorporated into haemoglobin in 3–4 weeks and the iron stores replenished rapidly. Using organ scanning, the liver was confirmed as the site of primary plasma clearance, but accumulations of iron were also detected in the spleen and bone marrow. Only minute quantities of radioactivity appeared in the urine. No untoward effects on iron metabolism have been detected, but reduction of the serum iron and total iron binding capacity to low levels 6 weeks post infusion is of interest. An attempt has been made to interpret the findings to elucidate the ferrokinetics of this method of treatment.