Premium
The Effect of Enteral and Parenteral Iron on Ferritin Synthesis in the Intestinal Mucosa of the Rat
Author(s) -
Smith J. A.,
Drysdale J. W.,
Goldberg A.,
Munro H. N.
Publication year - 1968
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1968.tb01475.x
Subject(s) - ferritin , enteral administration , spleen , excretion , intestinal mucosa , medicine , iron deficiency , chemistry , endocrinology , parenteral nutrition , biology , anemia
S ummary It has been suggested that the iron incorporated into ferritin of intestinal mucosa provides a means for the excretion of unrequired iron. In iron deficiency there is little mucosal ferritin but in states of iron repletion there is ample. In the present study oral and parenteral administration of iron in the rat caused a three‐ and ten‐fold increase, respectively, in ferritin synthesis in intestinal mucosa, assayed by the rate of incorporation of 1– 14 C‐dl‐leucine into ferritin. Small‐scale isolation of mucosal ferritin was achieved by using a specific antiserum prepared by injection of horse spleen ferritin into rabbits. These results help to explain how iron absorption and excretion may be controlled by the iron content of the body.