Premium
VIII. EFFECT OF HYPOXIA AND POST‐HYPOXIC POLYCYTHAEMIA (REBOUND) ON MOUSE MARROW AND SPLEEN
Author(s) -
Turner M. S.,
Hurst J. M.,
Yoffey J. M.
Publication year - 1967
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1967.tb08864.x
Subject(s) - erythropoiesis , polycythaemia , hypoxia (environmental) , spleen , bone marrow , stem cell , ineffective erythropoiesis , biology , haematopoiesis , guinea pig , medicine , endocrinology , immunology , chemistry , microbiology and biotechnology , oxygen , anemia , organic chemistry
SUMMARY Quantitative marrow changes, 59 Fe incorporation into erythrocytes and spleen weight variations have been studied in mice during primary hypoxia and rebound. The pattern of the mouse response to hypoxia is similar to that already described in the guinea‐pig. The possible involvement of the lymphocyte in erythropoiesis whether as stem cell or otherwise is suggested by the fact that its accumulation in the marrow seems to be inversely related to erythropoietic activity. The effect of hypoxia on the stem cell compartment is discussed.