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Haematological Changes in Malignancy
Author(s) -
Banerjee R. N.,
Narang R. M.
Publication year - 1967
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1967.tb08854.x
Subject(s) - medicine , incidence (geometry) , malignancy , etiology , gastroenterology , iron deficiency , hematological malignancy , disease , eosinophilia , erythrocyte sedimentation rate , aplastic anemia , bone marrow , physiology , pathology , anemia , physics , optics
SUMMARY 1. Detailed haematological investigations were carried out in 65 cases of malignant disease of different types. 2. Anaemia was found to be the commonest haematological disorder (83 per cent). 3. Seventy per cent of the cases showed features of simple chronic anaemia while four out of 16 selected cases showed evidence of shortened red cell life span. Incidence of myelophthisic, aplastic and iron deficiency anaemias were found to be 8, 3 and 3 per cent, respectively. 4. The study of iron metabolism revealed a high incidence (71 per cent) of hypoferraemia with shortened plasma iron ( 59 Fe) disappearance time, increased iron turnover rate but poor 59 Fe localization and iron utilization by bone marrow. 5. Other significant haematological disorders noted were leucocytosis, eosinophilia, thrombocytopenia and raised erythrocyte sedimentation rate. The possible implications have been discussed. 6. Nearly 50 per cent of the cases, mostly of reticulosis and sarcomatous groups, showed a significant increase in the total blood volume and plasma volume. 7. Possible aetiological correlation between malignant disease and the dominant haematological disorders found in malignant disease have been discussed.