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Absorption of Vitamin B 12 in Patients with Anaemia after Polya Partial Gastrectomy
Author(s) -
Turnbull A. L.
Publication year - 1967
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1967.tb08841.x
Subject(s) - intrinsic factor , pernicious anaemia , histamine , vitamin , cyanocobalamin , vitamin b12 , gastrectomy , medicine , absorption (acoustics) , vitamin b , gastroenterology , endocrinology , chemistry , cancer , physics , acoustics
SUMMARY The absorption of radioactive vitamin B 12 (cyanocobalamin) has been studied by the Schilling procedure in 27 patients with anaemia after Polya partial gastrectomy and in 10 patients with Addisonian pernicious anaemia. In patients who have had Polya partial gastrectomy absorption of vitamin B 12 was often increased when the dose was given with a meal containing only a small quantity of the vitamin, and when the dose was given after an injection of histamine. In the patients with pernicious anaemia histamine did not enhance absorption of vitamin B 12 , and food did not alter the absorption of the vitamin when given with a small quantity of intrinsic factor. Improved absorption of vitamin B 12 with food or after histamine is likely to be due to stimulation of a small residual secretion of intrinsic factor. The results of the standard fasting Schilling test appeared to correlate better with the development of deficiency of vitamin B 12 than tests with food or after histamine.