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Relationship between Membrane Function and Permeability
Author(s) -
Cohen Phin
Publication year - 1967
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1967.tb08839.x
Subject(s) - platelet , osmotic concentration , membrane , glycerol , chemistry , permeability (electromagnetism) , biophysics , cell , red blood cell , cell membrane , membrane permeability , biochemistry , microbiology and biotechnology , immunology , biology
SUMMARY As the osmolarity of the medium decreases, ‘platelet factor‐3’ (PF‐3) availability increases in erythrocyte as well as platelet suspensions. Associated with this is a parallel increase in PF‐3 activity of the cell‐free supernatant. Addition of glycerol to platelet or erythrocyte suspensions enhances PF‐3 availability of the cell suspensions but not the cell‐free supernatants. It is proposed that glycerol influx alters the orientation or binding of membrane thromboplastic phospholipids, thereby facilitating their reactivity in the PF‐3 assay.