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Quinine‐Induced Haemolysis: Mechanism of Action
Author(s) -
Bennett J. M.,
Desforges Jane F.
Publication year - 1967
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1967.tb08836.x
Subject(s) - haemolysis , quinine , hemolysis , tonicity , pentose phosphate pathway , pharmacology , mechanism of action , chemistry , red blood cell , in vitro , biochemistry , medicine , enzyme , glycolysis , immunology , malaria
SUMMARY Quinine hydrochloride was found to produce striking haemolysis of whole blood in vitro , preceded by rounding of red cells, K+ leakage, and decreased resistance to hypotonic saline solutions. Evidence is presented to indicate that quinine does not interfere with the pentose phosphate pathway. Its primary damage may be on membranes and is possibly‐related to oxidation of sulphhydryl groups.