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Regulation of Platelet Production: ‘Hypersplenism’ in the Experimental Animal
Author(s) -
Gabriele Geswalda de,
Penington D. G.
Publication year - 1967
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1967.tb08753.x
Subject(s) - platelet , spleen , mean platelet volume , medicine , immunology , endocrinology
SUMMARY The distribution and survival of 51 Cr‐labelled platelets in normal, splenectomized and ‘hypersplenic’ rats together with calculation of the total body platelets demonstrate that the influence of the spleen on the circulating platelet count is primarily due to pooling of platelets, the size of the pool being related to splenic size. In states of normal platelet production splenic enlargement would be associated with reduction in the circulating platelet count.