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Accumulation of Iron in Mitochondria of Erythroblasts
Author(s) -
Goodman J. R.,
Hall S. G.
Publication year - 1967
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1967.tb08748.x
Subject(s) - porphyria cutanea tarda , mitochondrion , chloramphenicol , etiology , anemia , physiology , hemochromatosis , biology , medicine , immunology , chemistry , pathology , biochemistry , antibiotics
SUMMARY Abnormal accumulations of iron in the mitochondria of erythroblasts were observed in patients who developed mild transitory anaemia while on a course of chloramphenicol and in patients with porphyria cutanea tarda. These and similar observations in six other syndromes were the basis for a discussion of the biochemical aetiology of this increased deposition of iron.