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The Effect of Cortisol on the Rate of Autohaemolysis of Red Cells Incubated in vitro
Author(s) -
Morley A. A.
Publication year - 1967
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1967.tb08745.x
Subject(s) - haemolysis , in vitro , lysis , endocrinology , medicine , red cell , hydrocortisone , mineralocorticoid , biology , glucocorticoid , chemistry , immunology , biochemistry
SUMMARY Evidence is presented for a direct effect of cortisol on the rate of red cell lysis in vitro. It is suggested that this effect is due to the mineralocorticoid action of cortisol. The finding may be relevant to certain disease states especially paroxysmal nocturnal haemoglobinuria, in which the rate of haemolysis is inversely related to plasma steroid levels.