Premium
Effects of Human Plasma on Thrombelastographic Patterns Produced by Fibrinolytic Agents in Fibrin Clots
Author(s) -
Egeblad Klas,
Astrup Tage
Publication year - 1967
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1967.tb08690.x
Subject(s) - plasmin , fibrin , chemistry , streptokinase , plasminogen activator , platelet , fibrinolysis , urokinase , thrombelastography , immunology , medicine , biochemistry , enzyme , myocardial infarction
SUMMARY A comparative study is presented of the thrombelastographic patterns produced by, and the curves correlating concentration and activity of, fibrinolytic agents incorporated in a bovine fibrin clot containing various amounts of human plasma. Except for a delay of lysis the thrombelastographic patterns produced by plasmin in the simple fibrin clot are in principle retained in the presence of plasma. An interference of plasmin with clot structure is revealed by a decreased maximum amplitude. The slopes of the plasmin correlation curves are considerably increased in the presence of plasma. Urokinase and SK‐activator (streptokinase+ human globulin) produced the same thrombelastographic pattern in the simple fibrin clot as in the presence of plasma except that at low concentrations of SK‐activator a prolongation of the end phase occurred. This was even more pronounced when SK‐resistant plasma was used. In this case also the correlation curves became steep. With urokinase and plasmin the SK‐resistant plasma showed the patterns produced by normal plasma. Platelets interfere strongly with clot formation and final clot structure. There is a large increase in maximum amplitude. The antifibrinolytic effect of platelets is mainly directed against plasmin.