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Studies on Neutrophil Function. II. PATHOLOGICAL ASPECTS
Author(s) -
Penny R.,
Galton D. A. G.
Publication year - 1966
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1966.tb00146.x
Subject(s) - phagocytosis , pathological , immunology , neutrophile , granulocyte , function (biology) , biology , chemistry , inflammation , medicine , pathology , microbiology and biotechnology
The functional capacities of mature neutrophils in disease have been less studied than their biochemical, cytogenetic and cytochemical characteristics. It is surprising that the biochemical and other abnormalities revealed in recent years have not been related to functional capacity. In the present study two features of neutrophil function have been examined: they are first, the capacity of the neutrophils to adhere to glass, as shown by the reduction in the proportion of cells emerging after the passage of blood through a column of minute glass beads; and second, the capacity of the neutrophils to phagocytose heat‐killed yeast cells. By these simple means, applied to the blood of normal subjects and of patients, it has been possible to examine the relationship between the adhesiveness of the neutrophils and their capacity for phagocytosis, and the dependence of each activity on factors intrinsic to the neutrophils and on extrinsic factors. The physiological aspects of the work have been reported in the preceding paper (Penny, Galton, Scott and Eisen, 1966).