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Changes in Iron Mobilization and Utilization Induced by Acute Haemorrhage
Author(s) -
Meital V.,
Izak G.,
Rachmilewitz M.
Publication year - 1966
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1966.tb00143.x
Subject(s) - erythropoietin , finch , red cell , iron isotopes , bone marrow , chemistry , erythropoiesis , physiology , anemia , endocrinology , isotope , medicine , biology , zoology , physics , quantum mechanics
T he measurement of the rate of appearance in the circulating blood of radioactive iron that has been previously injected is one of the most convenient techniques in the study of red‐cell production. Using this isotope, Dubach, Moore and Minnich (1946), Dubach, Callender and Moore (1948), Saylor and Finch (1953) and Dubach, Moore and Callender (1955) reported observations on the mechanism of the absorption of iron and its deposition in the storage organs. Jandl, Inman, Simmons and Allen (1959) and Morgan and Laurell (1963) described the competition between the reticulocytes and the iron‐binding protein of plasma for iron. Lamerton, Belcher and Harris (1959), Stohlman (1959), Donohue, Gabrio and Finch (1958), Bothwell, Pribilla, Mebust and Finch (1958) and others examined the uptake of iron by the early erythroid precursors in human and animal bone marrow. Stohlman (1959), Alpen and Cranmore (1959) and others examined the relationship between the incorporation of 59 Fe into erythroid precursors and the release of mature red cells into the circulation. Information concerning iron absorption, utilization, storage and mobilization in iron‐deficiency anaemia due to chronic blood loss is also abundant. The present paper deals with the erythropoietic response as measured by ferrokinetic studies in the rat following acute haemorrhage. Evidence will be presented to show that this response is different from that produced by erythropoietin administration to the rat.