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Granulocytopoiesis in the Rat Thymus
Author(s) -
Sin Yoke Min,
SainteMarie G.
Publication year - 1965
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1965.tb00109.x
Subject(s) - mitosis , nucleus , biology , cell type , microbiology and biotechnology , process (computing) , cell , bone marrow , granulocyte , immunology , genetics , computer science , operating system
I t is known that in the process of granulocytopoiesis the myeloblast matures into segmented granulocytes by way of intermediate cell types and that some of the immature cells of the granulocytic series enter into mitosis. Three main aspects of granulocytopoiesis remain to be clarified: first, the number of intermediate cell types formed during this process; second, the morphological changes accounting for the transformation of the oval nucleus of the myeloblast into the segmented nucleus of the mature cells; and third, which cell types of the series undergo mitosis. The present work is an attempt to clarify these aspects of granulocytopoiesis. This process should be most readily studied by analysis of islands of cells representing the progeny of a single myeloblast, each island being in some stage of the process. In bone marrow such islands cannot be distinguished clearly, but in the rat thymus, fairly well outlined islands of granulocytic cells have been described (Weidenreich, 1912; Weill, 1913; Harland, 1940; Sainte‐Marie, 1962). Accordingly, these islands were analysed as to their cell composition. This paper deals with the morphological aspects of granulocytopoiesis. In a second paper, a quantitative analysis of these islands will be reported with a proposal of a pattern for granulocyte formation.