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Haemopoietic Changes in the Rat during Growth and during Continuous Gamma Irradiation of the Adult Animal
Author(s) -
Lord B. I.
Publication year - 1965
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1965.tb00097.x
Subject(s) - haematopoiesis , spleen , bone marrow , biology , cell growth , blood cell , population , gamma irradiation , immunology , stem cell , microbiology and biotechnology , andrology , endocrinology , medicine , irradiation , biochemistry , physics , environmental health , nuclear physics
I n this report, the changing patterns of cell proliferation in the various haemopoietic tissues (in particular the bone marrow and the spleen of the rat) are studied in relation to one another and to the changing requirements for blood production during growth. Particular attention is given to the erythropoietic system. In addition, haemopoiesis during growth involves maintaining the cellular content of an expanding blood volume and previous work (Lamerton, Pontifex, Blackett and Adams, 1960; Lord, 1964) has shown that the cellular content of the blood can be maintained in spite of a greatly depleted marrow cell population. Therefore, changes in cell proliferation in the bone marrow and spleen of adult rats following doses of continuous whole‐body γ‐irradiation are also studied. These changes are compared with those taking place during growth.