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Haemophilia, Christmas Disease and the Xg Blood Groups
Author(s) -
Harrison J. F.
Publication year - 1964
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1964.tb00684.x
Subject(s) - medicine , population , haemophilia , blindness , genetics , pediatrics , biology , optometry , environmental health
I n 1954 the Medical Research Council and the Ministry of Health jointly asked various clinics and laboratories to act as reference centres for patients with hereditary bleeding diseases. In the following study, the register at one such centre has been used to trace families who might help determine the degree of linkage between haemophilia and Christmas disease and the X‐borne Xg blood groups. Information has also been obtained on the incidence of the two diseases. Mann, Cahan, Gelb, Fisher, Hamper, Tippett, Sanger and Race (1962) reported the discovery of the Xg system. Two alleles, Xg a and Xg, are so far known; the antigen Xg a is a dominant character and occurs in about 66 per cent of the male and 88 per cent of the female white population. Accounts have now appeared of attempts to measure linkage between Xg and colour blindness (Jackson, Symon and Mann, 1962), glucose‐6‐phosphate dehydrogenase (G6PD) deficiency (Adam, Sheba, Sanger, Race, Tippett, Hamper, Gavin and Finney, 1963), Duchenne muscular dystrophy (Clark, Puite, Marczynski and Mann, 1963), and haemophilia and Christmas disease (Davies et al. , 1963). Lindsten, Fraccaro, Polani, Hamerton, Sanger and Race (1963) used the Xg blood groups to study 14 patients with an isochromosome for the long arm of the X, and suggested, with certain reservations, that the deutan colour blindness and Xg loci both lie on the short arm of the X chromosome.