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Erythrocyte sedimentation rate as an independent prognostic factor in mycosis fungoides
Author(s) -
Hallermann C.,
Niermann C.,
Fischer R.J.,
Schulze H.J.
Publication year - 2012
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.2011.10729.x
Subject(s) - mycosis fungoides , medicine , erythrocyte sedimentation rate , dermatology , stage (stratigraphy) , cutaneous t cell lymphoma , retrospective cohort study , mycosis , lymphoma , pathology , oncology , surgery , biology , paleontology
Summary Background Mycosis fungoides has a characteristically indolent clinical course, with a slow progression from patches over plaques to tumours. In advanced stages, with generalized skin involvement or tumours, the prognosis is poor. Well defined prognostic parameters for the individual risc stratifications are rare. Objectives To determine prognostic factors for mycosis fungoides. Methods In a retrospective monocenter study, we reevaluated 97 consecutive cases of mycosis fungoides seen at our clinic. We correlated various routinely accessed parameters with survival data. The parameters were “sex”, “age at time of diagnosis”, “age‐adjusted erythrocyte sedimentation rate”?(ESR), and “anemia”. Results We identified ESR as a highly significant prognostic marker for MF that also affects overall survival and disease specific survival ( P = 0·0014). The five‐years disease specific survival was 100% for patients without elevation of ESR, and 52·83% for patients with elevated ESR above normal range ( P < 0·001). It is of main interest that the ESR is a significant prognostic marker also in the T2 stage of MF. For the other parameters there was no significant impact on disease specific survival. Conclusions ESR has turned out as independent prognostic factor in mycosis fungoides.