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Vitamin D status in patients with chronic plaque psoriasis
Author(s) -
Gisondi P.,
Rossini M.,
Di Cesare A.,
Idolazzi L.,
Farina S.,
Beltrami G.,
Peris K.,
Girolomoni G.
Publication year - 2012
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.2011.10699.x
Subject(s) - psoriasis , medicine , vitamin d and neurology , vitamin d deficiency , psoriatic arthritis , rheumatoid arthritis , parathyroid hormone , body mass index , gastroenterology , psoriasis area and severity index , blood sampling , endocrinology , calcium , immunology
Summary Background Vitamin D could have important immunomodulatory effects in psoriasis. Objectives To measure 25‐hydroxyvitamin D [25(OH)D], parathyroid hormone (PTH) and calcium serum levels in patients with psoriasis and the associations with some relevant clinical features. Methods A cross‐sectional study was conducted over 1 year including 145 patients with chronic plaque psoriasis, 112 patients with rheumatoid arthritis (RA) and 141 healthy controls. 25(OH)D, PTH and calcium serum levels were measured in a centralized laboratory. Demography, comorbidities, disease severity and exposure time to sunlight (which was derived by questionnaire) were collected. Results The prevalence of vitamin D deficiency [25(OH)D levels < 20 ng mL −1 ] in patients with psoriasis was 57·8% vs. 37·5% in patients with RA and 29·7% in healthy controls ( P < 0·001). In winter, the prevalence of vitamin D deficiency rose to 80·9% in patients with psoriasis, to 41·3% in those with RA and to 30·3% in healthy controls ( P < 0·001). Patients with psoriasis or psoriatic arthritis did not differ in 25(OH)D serum levels nor in the prevalence of vitamin D deficiency. In the logistic regression analysis, vitamin D deficiency was associated with psoriasis independently of age, sex, body mass index, calcium, PTH levels and season of blood sampling. A limitation is that the study design does not allow a causal or temporal relationship between vitamin D deficiency and psoriasis to be established. Conclusions Vitamin D deficiency may be common in patients with psoriasis, especially in winter.