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Immunosuppressive effect of prolactin‐induced protein: a new insight into its local and systemic role in chronic allergic contact dermatitis
Author(s) -
Sugiura S.,
Fujimiya M.,
Ebise H.,
Miyahira Y.,
Kato I.,
Sugiura Y.,
Kimura T.,
Uehara M.,
Sato H.,
Sugiura H.
Publication year - 2010
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.2010.09756.x
Subject(s) - allergic contact dermatitis , medicine , prolactin , immunology , allergy , dermatology , hormone
Summary Background Prolactin‐induced protein (PIP) has been shown to bind to CD4 and is speculated to block CD4–HLA‐DR interaction. However, the immunomodulatory effect of PIP on chronic allergic contact dermatitis (ACD) remains to be elucidated. Objectives To define the role of PIP during the immunoresponse. Methods Using a low‐dose oxazolone‐induced mouse chronic ACD model, expression of PIP was examined immunohistologically. Furthermore, effects of continued exposure to a peptide mimicking the major binding site of PIP (amino acids 106–132) for CD4 was examined in a mouse chronic ACD model. Results We clarified that keratinocytes, dermal infiltrating cells and spleen infiltrating mononuclear cells are positively stained with anti‐PIP antibody. The PIP peptide significantly downregulated oxazolone‐induced mouse ACD compared with controls. We also found that inflammation of the control ear, to which the PIP peptide had not been applied, was also suppressed in a synchronized manner in the late phase of ACD. Conclusions These findings suggest that PIP might have a local and systemic immunosuppressive effect in mouse chronic ACD.