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Ultraviolet radiation and immunosuppression
Author(s) -
Murphy G.M.
Publication year - 2009
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.2009.09455.x
Subject(s) - immunosuppression , context (archaeology) , carcinogen , ultraviolet radiation , ultraviolet , cancer research , medicine , dermatology , biology , immunology , chemistry , physics , genetics , optics , radiochemistry , paleontology
Summary Ultraviolet (UV) radiation is a complete carcinogen. The effects of UV radiation are mediated via direct damage to cellular DNA in the skin and suppression of image surveillance mechanisms. In the context of organ transplantation, addiction of drugs which suppress the immune system add greatly to the carcinogenicity of UV radiation. This review considers the mechanisms of such effects.