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Extranodal NK / T‐cell lymphoma with cutaneous involvement: ‘nasal’ vs. ‘nasal‐type’ subgroups— a retrospective study of 18 patients
Author(s) -
Choi YL.,
Park JH.,
Namkung JH.,
Lee JH.,
Yang JM.,
Lee ES.,
Lee DY.,
Jang KT.,
Ko YH.
Publication year - 2009
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.2008.08922.x
Subject(s) - medicine , lymphoma , retrospective cohort study , dermatology , t cell lymphoma , pathology
Summary Background Extranodal natural killer T (NK/T) cell lymphoma is subcategorized into ‘nasal’ and ‘nasal‐type’ NK/T‐cell lymphomas according to the primary sites of anatomical involvement. Objectives The aim of this study was to characterize the cutaneous manifestations of the skin involving extranodal NK/T‐cell lymphoma and to define the distinctive features of ‘nasal’ and ‘nasal‐type’. In addition, the prognostic factors that affect overall survival were investigated. Methods A retrospective case study of 18 patients with extranodal NK/T‐cell lymphoma with cutaneous involvement was performed. Results The NK/T‐cell lymphomas usually occurred in middle‐aged, male patients. Most of the patients presented with either cellulitis or ulcer. A facial predilection for the location of the lesion was noted. The characteristic features of the ‘nasal‐type’ compared with the ‘nasal’ were a localized involvement of the skin, less aggressive clinical course and better survival outcome. Conclusions Extranodal NK/T‐cell lymphomas are extremely aggressive regardless of their subgroup. However, the ‘nasal‐type’ NK/T‐cell lymphoma was clinically less aggressive, more localized and had a better outcome compared with the other type. Cellulitis and ulcer were the major cutaneous manifestations.