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Metastatic ovarian carcinoma‐associated subepidermal blistering disease with autoantibodies to both the p200 dermal antigen and the γ2 subunit of laminin 5 showing unusual clinical features
Author(s) -
Mitsuya J.,
Hara H.,
Ito K.,
Ishii N.,
Hashimoto T.,
Terui T.
Publication year - 2008
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.2008.08483.x
Subject(s) - laminin , autoantibody , basement membrane , medicine , pathology , pemphigoid , antigen , lamina lucida , bullous pemphigoid , ovarian carcinoma , extracellular matrix , immunology , cancer , antibody , biology , ovarian cancer , microbiology and biotechnology
Summary Anti‐p200 pemphigoid is an autoimmune subepidermal blistering disease characterized by autoantibodies to an unknown 200‐kDa acidic noncollagenous glycoprotein of the lower lamina lucida, whereas antilaminin 5 mucous membrane pemphigoid is characterized by autoantibodies to a major basement membrane extracellular matrix, laminin 5. We report a 64‐year‐old Japanese woman with a subepidermal blistering disease associated with lymph node metastasis of ovarian clear cell carcinoma 10 years after its surgical treatment. Clinical features showed severe blisters and erosions on multiple mucous membranes (i.e. lip, oral cavity, nose, eye, genitalia and anus) and on both the periungual and subungual regions. This is the first report in which an immunoblot analysis revealed the unusual combination of autoantibodies to both the p200 antigen and the γ2 subunit of laminin 5.