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Acute myeloid dendritic cell leukaemia with specific cutaneous involvement: a diagnostic challenge
Author(s) -
Ferran M.,
Gallardo F.,
Ferrer A.M.,
Salar A.,
PérezVila E.,
Juanpere N.,
Salgado R.,
Espinet B.,
Orfao A.,
Florensa L.,
Pujol R.M.
Publication year - 2008
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.2008.08480.x
Subject(s) - myeloid , medicine , dendritic cell , pathology , plasmacytoid dendritic cell , immunohistochemistry , immunophenotyping , neoplasm , myeloid leukaemia , haematopoiesis , immunology , biology , antigen , stem cell , genetics
Summary Myeloid or type 1 dendritic cell leukaemia is an exceedingly rare haematopoietic neoplasm characterized by a specific immunophenotypic profile close to plasmacytoid dendritic cell and acute myelogenous leukaemia. A 77‐year‐old man presenting specific cutaneous infiltration by myeloid dendritic cell leukaemia is reported. The clinical features as well as the cutaneous histopathological and immunohistochemical features led to the initial diagnosis of CD4+/CD56+ haematodermic neoplasm. However, extensive immunophenotypic studies performed from peripheral blood blasts disclosed that leukaemic cells expressed myeloid dendritic cell markers, confirming the diagnosis. The diagnostic difficulties of specific cutaneous involvement by myeloid dendritic cell leukaemia on the basis of routine histopathological and immunohistochemical features are highlighted.