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Gadolinium‐induced nephrogenic systemic fibrosis in a patient with an acute and transient kidney injury
Author(s) -
Kalb R.E.,
Helm T.N.,
Sperry H.,
Thakral C.,
Abraham J.L.,
Kanal E.
Publication year - 2008
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.2007.08369.x
Subject(s) - nephrogenic systemic fibrosis , medicine , acute kidney injury , gadolinium , fibrosis , transient (computer programming) , kidney , pathology , radiology , kidney disease , chemistry , organic chemistry , computer science , operating system
Summary Nephrogenic systemic fibrosis (NSF) describes a characteristic fibrosing disorder which typically presents with indurated plaques on the trunk and extremities of patients with advanced renal disease. We present a case of biopsy‐confirmed NSF in a patient with severe acute kidney injury with no prior history of renal disease. A 64‐year‐old man with an acute and severe decrease in glomerular filtration rate underwent magnetic resonance imaging studies with gadolinium contrast (Omniscan™) and subsequently developed NSF. His renal disease had normalized at the time his skin disease developed. Skin biopsies revealed findings of NSF and scanning electron microscopy with energy‐dispersive X‐ray spectroscopy confirmed insoluble gadolinium within lesional tissue.