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Update on the pathogenesis of post‐transplant skin cancer in renal transplant recipients
Author(s) -
Ho W.L.,
Murphy G.M.
Publication year - 2008
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.2007.08363.x
Subject(s) - medicine , skin cancer , renal transplant , dermatology , family medicine , cancer , library science , transplantation , surgery , computer science
Summary Remarkable advances in the field of transplantation over the last several decades have benefited many thousands of patients. Five‐year survival ranges from 90% for a live donor renal transplant to 85% for a cadaveric renal transplant. However, with this success come the complications of chronic immunosuppression. Lifelong immunosuppressive treatment for adequate graft function results in reduction of immunosurveillance, with increased risk of various cancers leading to substantial morbidity and mortality in these patients. This review discusses multifactorial intrinsic and extrinsic factors contributing to the pathogenesis of skin cancers in renal transplant recipients and reviews potential solutions.