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Genetics of melanoma tumorigenesis
Author(s) -
Singh M.,
Lin J.,
Hocker T.L.,
Tsao H.
Publication year - 2008
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.2007.08316.x
Subject(s) - carcinogenesis , melanoma , identification (biology) , computational biology , cancer research , mutation , biology , genetics , gene , signalling pathways , targeted therapy , medicine , bioinformatics , cancer , botany
Summary Melanoma therapy is moving away from combinatorial approaches and towards newer targeted strategies. With the identification of mutations in various RAS pathway genes, there are now tremendous opportunities to bring inhibitors of RAS signalling to the clinical arena.