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Post‐kala‐azar dermal leishmaniasis as an immune reconstitution inflammatory syndrome in a patient with acquired immune deficiency syndrome
Author(s) -
Antinori S.,
Longhi E.,
Bestetti G.,
Piolini R.,
Acquaviva V.,
Foschi A.,
Trovati S.,
Parravicini C.,
Corbellino M.,
Meroni L.
Publication year - 2007
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.2007.08157.x
Subject(s) - visceral leishmaniasis , medicine , immune system , leishmaniasis , immune reconstitution inflammatory syndrome , immunology , immunopathology , leishmania , human immunodeficiency virus (hiv) , dermatology , antiretroviral therapy , viral load , parasite hosting , computer science , world wide web
Summary Post‐kala‐azar dermal leishmaniasis (PKDL) is a complication of visceral leishmaniasis (VL) observed mainly in Sudan and India where it follows treated VL in 50% and 10% of cases, respectively. We report a 46‐year‐old patient with acquired immune deficiency syndrome who, 7 months after diagnosis of VL, developed PKDL and uveal leishmaniasis following HAART‐induced immune recovery. In southern Europe PKDL seems to be an emerging clinical presentation among human immunodeficiency virus (HIV)‐infected patients experiencing HAART‐induced immune recovery after a previous diagnosis of VL. The best treatment among HIV‐infected patients remains to be determined.