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Nephrogenic systemic fibrosis: a case series suggesting gadolinium as a possible aetiological factor
Author(s) -
MorenoRomero J.A.,
Segura S.,
Mascaró J.M.,
Cowper S.E.,
Julià M.,
Poch E.,
Botey A.,
Herrero C.
Publication year - 2007
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.2007.08067.x
Subject(s) - nephrogenic systemic fibrosis , gadolinium , medicine , etiology , magnetic resonance imaging , fibrosis , kidney disease , pathology , disease , natural history , radiology , materials science , metallurgy
Summary Nephrogenic systemic fibrosis (NSF) or nephrogenic fibrosing dermopathy is a rare fibrotic condition that presents in patients with a history of renal disease. The aetiology is unknown, but it has recently been proposed that gadolinium, a paramagnetic contrast agent, may be a trigger of this disease. We report three patients with NSF with a history of use of gadolinium in magnetic resonance angiography a few weeks before the onset of symptoms. In the future, gadolinium should probably be avoided as much as possible in renal insufficiency patients until its role in the development of NSF is clarified.