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Alteration of extracellular matrix modulators after nonablative laser therapy in skin rejuvenation
Author(s) -
Oh J.,
Kim N.,
Seo S.,
Kim IH.
Publication year - 2007
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.2007.08061.x
Subject(s) - rejuvenation , medicine , laser therapy , dermatology , extracellular matrix , cosmetic techniques , surgery , laser , chemistry , optics , physics , biochemistry
Summary Background Nonablative laser therapy is widely practised for skin rejuvenation, which stimulates collagen production and dermal matrix remodelling. Matrix remodelling is primarily modulated by a coordinated action of matrix metalloproteinases (MMPs) and their inhibitors, but the effects of nonablative lasers on these matrix modulators are not fully investigated. Objectives To evaluate the changes in matrix modulators, such as MMP‐1, MMP‐2, MMP‐3, MMP‐9 and MT1‐MMP, and their inhibitors (TIMP‐1, TIMP‐2 and RECK in particular), after nonablative laser treatments of human facial skin. Methods Twenty‐four adult volunteers received a series of four nonablative laser treatments separated by 3‐week intervals on facial skin. Two‐millimetre skin punch biopsies were obtained at baseline and 3 weeks after the last treatment. Results Nonablative laser treatments led to a robust increase in two major dermal matrix components, type I collagen and tropoelastin. Among MMPs tested, levels of MMP‐2 mRNA were statistically significantly increased, but the amount of active MMP‐2 was rather reduced. More importantly, the expression level of RECK was significantly enhanced by laser treatments. Conclusions Clinical outcomes following nonablative laser treatments may result not only from increased biosynthesis but also from decreased degradation, via an induction of RECK expression, of matrix proteins.