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Erythema gyratum repens‐like eruption in a patient with epidermolysis bullosa acquisita associated with ulcerative colitis
Author(s) -
España A.,
Sitaru C.,
Pretel M.,
Aguado L.,
Jimenez J.
Publication year - 2007
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.2006.07746.x
Subject(s) - medicine , dermatology , family medicine
anocyte supernatants after 0Æ5, 6, 24, 48 and 72 h. A slight increase in S100b can be observed even in the controls, but the difference between control and irradiated cells increases over time after irradiation and is also dose dependent. We consider the slight increase of S100b level in controls to be caused either by the fact that cells could not be prepared in the total absence of light, resulting in melanocyte activation, or possibly by a cumulative increase of cell depletion. The cell doubling time was 45Æ6 h in both controls and irradiated cells, resulting in similar cell counts after each measurement. To our knowledge, we show for the first time that S100b levels in extracellular fluid derived from normal human skin melanocytes increase after irradiation with suberythemal as well as erythemal UVB doses. Taking this finding together with the observations of Tronnier et al., who found elevated serum S100b levels after UVB exposure in some individuals of a small group of volunteers, we conclude that UVB exposure of skin cells can indeed influence serum S100b levels. Further investigation is needed to provide correct interpretation of elevated S100b levels in dermatology as well as in neurology.